Isabella Rossellini appeared as herself in "The One With Frank Jr." when she walks into Central Perk for coffee. Earlier on in the episode, Ross had made a list of celebrities he was allowed to sleep with and cut Isabella out of the final laminated draft.

As Ross proceeds to hit on her, his friends watch on. She is bemused by his daft comments throughout this conversation, particularly when he mentions having a list of celebrities he'd like to sleep with and then making it pretty obvious that she is not on it, causing her to publicly humiliate him.

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