The first season of Joey aired from September 9, 2004 to May 12, 2005.
- Matt LeBlanc as Joey Tribbiani, who moves to Los Angeles from New York, to proceed with his acting career. He is constantly talking about food or eating sandwiches.
- Paulo Costanzo as Joey's nephew Michael Tribbiani who idolizes his Uncle Joey's ability to date many women, and who himself is sheltered and nervous around girls. He is self-conscious that he has been so sheltered and that his mother Gina breast fed him until he was seven. He is a huge Star Trek: The Next Generation and Star Wars fan. He is extremely intelligent, an aerospace engineer, attends Caltech and specializes in applied thermodynamics, works with his rival Seth frequently on engineering projects, and is an obvious direct opposite from his more street-wise mother and uncle.
- Drea de Matteo as Joey's attractive older sister Gina Tribbiani, who is temperamental and promiscuous. Not particularly bright but very street-wise, Gina is a caring but over-protective and domineering mother. For years she convinced her genius son Michael that he was born when she was 22, instead of 15 and always says he is the one thing she has done really well. She and Joey are friends in addition to being siblings, both having the gift of being extremely appealing to the opposite sex, with numerous lovers.
- Andrea Anders as Alexis "Alex" Garrett, the next door neighbour, landlord and friend. She is an educated, but slightly ditsy blonde lawyer who graduated from Pepperdine University. Initially intimidated, but also intrigued by Joey's tough street-wise older sister Gina, the two women eventually become friends, and she becomes more bold in the way she dresses and acts, thanks to Gina's influence. She is puzzled but impressed by Joey's gift at being able to know when she is wearing thong panties, and spends most of her time hanging out at Joey and Michael's apartment. She and Joey bond and become close friends, and she confides in him her problems with her marriage. Her husband is a professional orchestra musician and is away from home most of the time.
- Jennifer Coolidge as Joey's oversexed agent Roberta "Bobbie" Morganstern, and reportedly the 12th most powerful woman in Hollywood. She has an enormous crush on Joey's nephew Michael. She often entertains herself by making her office assistant do funny tricks, or shocking herself with a stun-gun. She is brash, forward, aggressive, highly entertaining and slightly ditsy, laughing at everything and at anyone's expense, including her client Joey's. She was once sued by Phil Collins.
|1||1||"Pilot"||Shana Goldberg-Meehan & Scott Silveri||Kevin S. Bright||September 8, 2004|
|When Joey's new TV show is cancelled and the show he turned down is a big hit, it leaves Joey kicking himself and in search of work. Joey's nephew wants to leave his mother's house and live with his cool uncle but is afraid to tell her.|
|2||2||"Joey and the Student"||Shana Goldberg-Meehan & Scott Silveri||Kevin S. Bright||September 16, 2004|
|When Joey plans to teach Michael how to pick up women, Gina invites herself along, even though the guys don't want her to come. Joey finds out that Alex is the one who has been placing complaint notes about everything he does and that everyone hates her because of this.|
|3||3||"Joey and the Party"||Robert Carlock||Gail Mancuso||September 23, 2004|
|Joey and Michael plan a party, with the hopes that Joey makes a new friend. Michael's college rival announces he'll be showing up with his girlfriend, Michael tries to compete by enlisting the help of Alex to play his fake girlfriend. Guest Star: Jayma Mays As Molly|
|4||4||"Joey and the Book Club"||John Quaintance||Andrew D. Weyman||September 30, 2004|
|To woo a girl in his book club, Michael assigns a romantic novel to the group. However, when he tries to make his move, he finds out that she is already in love with Joey. Gina makes a deal with Alex in order to get more work.|
|5||5||"Joey and the Perfect Storm"||Vanessa McCarthy||David Schwimmer||October 7, 2004|
|When Joey gets the job of understudying in three different plays, it leaves him in a tight spot when all three main actors call in sick. Meanwhile, there is a vacant apartment in the complex, and Joey, Michael, and Alex try to hide it from Gina.|
|6||6||"Joey and the Nemesis"||Sherry Bilsing-Graham & Ellen Plummer||Kevin S. Bright||October 14, 2004|
|An actor named Brian Michael David Scott repeatedly tricks Joey into missing auditions. When Michael gets sick, Gina moves into Joey's place to take care of him, and Joey moves to Gina's place to get away from them. However, when staying at Gina's, her secret boyfriend mistakes Joey for her, and snuggles up to him.|
|7||7||"Joey and the Husband"||Brian Kelley||Gail Mancuso||October 21, 2004|
|Joey finally meets Alex's husband, Eric, and is stunned when Eric is not threatened by him. Joey decides to donate his savings to Gina so she can open up her own salon, but she has second thoughts.|
|8||8||"Joey and the Dream Girl, Part 1"||Brian Buckner||Gary Halvorson||November 4, 2004|
|Gina's high school friend Donna, who Joey used to have a huge crush on, visits. Joey promises Gina he won't do anything with Donna but cannot resist. Michael learns he used to be a great baseball player when he was younger.|
|9||9||"Joey and the Dream Girl, Part 2"||Robert Carlock||Gary Halvorson||November 11, 2004|
|Joey tries to plan the perfect week for Donna, so she chooses him over her husband, who is attempting to reconcile with her. Alex discovers that she can get free stuff because she is a "hot girl".|
|10||10||"Joey and the Big Audition"||John Quaintance||Sheldon Epps||November 18, 2004|
|11||11||"Joey and the Road Trip"||Vanessa McCarthy||Kevin S. Bright||December 2, 2004|
|12||12||"Joey and the Plot Twist"||Story by John Pollack, Teleplay by Craig DeGregorio||Kevin S. Bright||December 9, 2004|
|13||13||"Joey and the Taste Test"||Shana Goldberg-Meehan & Scott Silveri||David Schwimmer||January 6, 2005|
|14||14||"Joey and the Premiere"||Matt Hubbard||Kevin S. Bright||January 13, 2005|
|15||15||"Joey and the Assistant"||John Quintance & Brian Kelley||Andrew D. Weyman||January 20, 2005|
|16||16||"Joey and the Tonight Show"||Doty Abrams||Andrew D. Weyman||February 3, 2005|
|17||17||"Joey and the Valentine's Date"||Story by Brian Kelley, Teleplay by Robert Carlock||Andrew D. Weyman||February 10, 2005|
|18||18||"Joey and the Wrong Name"||Story by Sherry Bilsing-Graham & Ellen Plummer, Teleplay by Matt Hubbard||Kevin S. Bright||February 17, 2005|
|19||19||"Joey and the Fancy Sister"||Robert Carlock & Brian Buckner||Gary Halvorson||February 24, 2005|
|20||20||"Joey and the Neighbor"||Story by Nicholas Darrow, Teleplay by Vanessa McCarthy||Gary Halvorson||March 24, 2005|
|21||21||"Joey and the Spying"||Story by Tracy Reilly, Teleplay by Brian Buckner||Kevin S. Bright||April 21, 2005|
|22||22||"Joey and the Temptation"||Story by Craig DeGregorio, Teleplay by Sherry Bilsing-Graham & Ellen Plummer||Sheldon Epps||May 5, 2005|
|23||23||"Joey and the Breakup"||Story by John Quintance, Teleplay by Nicholas Darrow||Andrew D. Weyman||May 12, 2005|
|24||24||"Joey and the Moving In"||Shana Goldberg-Meehan & Scott Silveri||Kevin S. Bright||May 12, 2005|