|Episode||The One With Rachel's Big Kiss|
|Portrayed by||Winona Ryder|
|Date of birth||-|
During senior year of college Melissa and Rachel went to the Sigma Chi luau and, after drinking too much sangria, went back to the house and ended up making out. Melissa fell in love with Rachel and never forgot that night, but Rachel never saw it as anything more than a wild college experience.
Rachel runs into Melissa in Central Perk and they go out to dinner. When Rachel confronts Melissa about the kiss, she pretends to have no memory of it ever happening because she doesn't think Rachel will return her love. At the end of dinner, Rachel kisses her again to prove to Phoebe that she can do something crazy. Melissa takes this to mean that Rachel loves her back. She says that "nobody can kiss that good and not mean it", but Rachel says that she is just a good kisser. Melissa is extremely embarrassed and tries to act as if she was kidding saying, "I'm not in love with you. I don't hear coconuts banging together Melissa leaves, but not before asking for another kiss goodbye.