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Outbreak 2: The Virus Takes Manhattan was a fictional film sequel to an actual film in the TV series Friends, which was being filmed in New York (as seen in "The One After The Superbowl, Part 1" and Part 2).

Ross' former pet monkey, Marcel starred in the film along with Jean-Claude Van Damme.

Susie Moss, a former classmate of Chandler's, did hair and make-up for the actors in the film, and Cathy was a director's assistant.

The creators of Friends Kevin Bright, Marta Kauffman and David Crane made an uncredited cameo appearance as the directors of the fictional film.

Joey got a small part in the film portraying a dying man. Because of his overacting, his role was changed into a dead man.

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